|
|
Use of cell phone in liquids analysis
Křístek, Tomáš ; Sekora, Jiří (referee) ; Čmiel, Vratislav (advisor)
Technological development, broad availability and ubiquity of mobile phones made it possible in recent years to start a progression leading to the integration of mobile phones into biomedical analytical methods, the development of telemedicine and mobile personal health applications. This paper deals with the literature review of the mobile phone usage in biomedicine, with emphasis on the methods of optical analysis and technical solutions using 3D printing technology. It provides a draft and practical implementation of salivary cortiol level measuring system using a mobile phone, ELISA analytical methods, 3D printing technology and a set of custom Matlab functions connected with Matlab Mobile application and Mathworks Cloud. Also provides critical evaluation of results and method possibilities, and presents set of proposals and findings for quality of measurment optimization.
|
|
|
Lanthanocene Catalysts for Synthesis of Polymers Applicable in Medicine
Slanina, Ondřej ; Kábelová, Božena (referee) ; Richtera, Lukáš (advisor)
The theoretic part of the thesis focuses on materials used in medicine. The metallic, ceramic, glass-ceramic and polymer materials are systematically described. The biocompatibility of the materials and possible threads of their usage for manufacturing of medicinal devices and implants are emphasized in the discussion. The work is focused especially on polymer materials. Different types of polymerizations are summarized with the accent on the preparation of biodegradable materials. In the practical part the synthesis of two organometallic bis(pentamethylcyclopentadienyl) sandwich complexes with holmium and gadolinium as a central atom designed for preparation of materials suitable for biomedicine is proposed.
|
|
|
Use of cell phone in liquids analysis
Křístek, Tomáš ; Sekora, Jiří (referee) ; Čmiel, Vratislav (advisor)
Technological development, broad availability and ubiquity of mobile phones made it possible in recent years to start a progression leading to the integration of mobile phones into biomedical analytical methods, the development of telemedicine and mobile personal health applications. This paper deals with the literature review of the mobile phone usage in biomedicine, with emphasis on the methods of optical analysis and technical solutions using 3D printing technology. It provides a draft and practical implementation of salivary cortiol level measuring system using a mobile phone, ELISA analytical methods, 3D printing technology and a set of custom Matlab functions connected with Matlab Mobile application and Mathworks Cloud. Also provides critical evaluation of results and method possibilities, and presents set of proposals and findings for quality of measurment optimization.
|
|
|
Bioresorbable polyurethanes with controlled mechanical properties
Letavaj, Emil ; Žídek, Jan (referee) ; Kupka, Vojtěch (advisor)
Presented diploma thesis deals with preparation of bioresorbable polyurethanes (PUR) and their characterization. The theoretical part describes the feedstocks used for the PUR preparation and summarizes the knowledge about PUR used in medical applications. Experimental part presents characterization of bioresorbable PUR films prepared by reactive casting in one step without the use of organic solvents. The absence of solvents represents a great advantage due to their toxicity and subsequent removal from the resulting product. The synthesis of PUR was conducted under an inert atmosphere by polyaddition reaction of hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) with hexamethylene diisocyanate (HDI). Synthesis under an inert atmosphere was necessary due to a side reaction of isocyanate with atmospheric humidity, which causes the formation of porous films instead of continuous ones. Prepared PUR films were characterized for different PCL/PEG ratios and different isocyanate index (ratio of NCO/OH reacted groups). PUR (isocyanate index 1.05) with PCL content 90 wt. % and higher demonstrated tought behavior in mechanical tests. Increase of isocyanate index and decrease of PCL content under 90 wt. % caused fragile sample behavior. The reason of such behavior was the different ability of PCL to crystallize in the structure of the polyurethane network. Increasing the PEG content has improved the ability of PUR films to absorb water and enhanced the rate of hydrolytic degradation. By adjusting the PCL/PEG ratio and the amount of isocyanate, solvent free bioresorbable PUR with suitable mechanical (flexibility, toughness) and physical properties (swelling, degradation) can be obtained. Prepared PUR films could be used in biomedicine e.g. as vascular grafts.
|
|
|
Detection, Localization and Determination of Chronic Wounds
Gulán, Filip ; Dvořák, Michal (referee) ; Drahanský, Martin (advisor)
The aim of this diploma thesis is to design and implement a multiplatform application for detection, localization and determination of the extent of chronic wounds. The application is intended to assist nurses, doctors and healthcare assistants to monitor and evaluate chronic wounds in the course of treatment. The application is based on the Typescript programming language, on the Ionic hybrid application framework and on the Electron desktop application framework. Chronic wound assessment runs on the server-side where the Python programming language is used. The Flask application framework is used for the RESTful application interface and the OpenCV library is used for image processing.
|
|
|
Application of clustering methods for processing of biomedical data
Rozinek, Michal ; Gazárek, Jiří (referee) ; Havlíček, Martin (advisor)
The goal of this study is to learn about methods in object classification in medicine and find out what are these methods about. Focusing on functionality and reliability of these methods whith datafile from the medicine compartment after making the algorithm in MATLAB. In form of siple tests, put the touch everyone of classification procedure and find out in which they excel and in which they lags. The choice of input data parametres is very important, this will be tested and noted in conclusions.
|
|
|
Epitaxial growth and characterization of metamagnetic nanoparticles for biomedical applications
Motyčková, Lucie ; Gröger,, Roman (referee) ; Arregi Uribeetxebarria, Jon Ander (advisor)
Magnetické nanočástice představují perspektivní prostředek pro široké množství biomedicínských aplikací v neustále se rozvíjejících oblastech diagnostiky a léčebné terapie. Využití magnetických nanočástic z metamagnetických materiálů by mohlo poskytnout výrazný přínos například z hlediska zlepšení ovladatelnosti biologických subjektů uvnitř lidského těla. Tato práce se zabývá růstovými mechanismy a magnetickými vlastnostmi nanočástic ze slitiny železa s rhodiem (FeRh) ukotvených na substrátu MgO. Slitina FeRh byla vybrána pro její specifickou fázovou přeměnu z antiferomagnetické do feromagnetické fáze nastávající v blízkosti pokojové teploty, což umožňuje ovládání magnetických vlastností nanočástic v teplotním rozsahu blízkém lidskému tělu. Prezentované nanostruktury jsou vyráběny magnetronovým naprašováním využívajícím přístup samouspořádání “bottom–up”. Morfologie a magnetické chování připravených nanostruktur jsou vyšetřovány pomocí mikroskopie atomových a magnetických sil, které umožňují získat prostorové rozložení feromagnetických a antiferomagnetických domén v jednotlivých nanoostrůvcích.
|
|
|
The role of topology and chemical composition of zeolites on their biomedical characteristics
Nováková, Denisa ; Grajciar, Lukáš (advisor) ; Rubeš, Miroslav (referee)
7 Abstract Zeolites are traditionally used materials in the petrochemical and chemical industry that have recently drawn attention for their possible utilization in biomedicine as drug and gene carriers, materials in bone tissue engineering, or adsorbents for detoxifying human organisms. Zeolites offer a possible solution for removing protein-binding uremic toxins, such as p-cresol, that are unremovable during classical hemodialysis. This bachelor's thesis focuses on analyzing the motion of water within zeolite with CAN framework topology using molecular dynamics simulations with neural network potentials. The obtained data is used to calculate the self-diffusion coefficients and analyze the effect of water loading, aluminum content, and the distribution of aluminum atoms on water diffusion and degree of deprotonation of Brønsted acid sites (BASs). In addition, the thoroughly tested water-loaded CAN models are used for evaluation of the interaction between the zeolite framework and water molecules and p-cresol in the context of potential application of zeolites for dialysis. Key words zeolites, machine learning, biomedicine, p-cresol, CAN
|
|
|
Selected Members of the Habsburg Dynasty and their Mental Disorders
Grunclová, Kateřina ; Ehler, Edvard (advisor) ; Vančata, Václav (referee)
This Bachelor thesis presents research into occurring mental illnesses in celected members of the Habsburg dynasty, with an effort to best consretise them from the original historical background and to compare them with current knowledge. At the same time, it will describe the marriage policy that cintributed to the emergence of mental illness in individual members. The aim of the work is to get acquainted with the Habsburg dynasty, characterize the mental disorders occurring in this magnificent dynasty and evaluate the manifestations of individual diseases.
|
|
|
Self-assembled polymer systems responsive to external stimuli for biomedicine
Sincari, Vladimir ; Štěpánek, Petr (advisor) ; Matějíček, Pavel (referee) ; Sedláková, Zdeňka (referee)
The first work in my doctoral thesis described a novel rapid and eco-friendly reversible addition-fragmentation chain transfer (RAFT) polymerization reaction of the N-(2- hydroxypropyl) methacrylamide (HPMA) monomer under microwave irradiation (MWI). Optimal conditions for the polymerization such as reaction time, solvents, monomer stoichiometry and RAFT agents was determined. The polymerization kinetics demonstrated the linear increase in the number-average molecular weight (Mn) with monomer conversion. Good agreement between the theoretical and experimental Mn values was verified with pseudo-first- order kinetic plots, with low dispersities (Đ ≤ 1.04). Furthermore, this publication demonstrated the ability of MWI to facilitate copolymer formation by the preparation of relevant copolymers, such as poly(HPMA-b-bocAPMA), poly(HPMA-b-MABH) and poly(HPMA-b-PDPA) which were used as a base for the following work in the thesis. The second and third study are devoted to delivery of therapeutic molecules by using cargo-delivery self-assemblies in the form of polymersomes (PS). Such drug delivery systems (DDS) potentially minimize the premature degradation of drug, fast clearance from bloodstream and dosing frequency which leads to lower toxicity. The main advantage of DDS is the controlled manner of drug...
|
guest ::
